Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 16 4 2017 10 07 210 217 EN Neda Soveyd Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mina Abdolahi Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Sama Bitarafan Iranian Centre of Neurological Research, Neuroscience institute, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Abbas Tafakhori Iranian Centre of Neurological Research, Neuroscience institute, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Payam Sarraf Iranian Centre of Neurological Research, Neuroscience institute, Department of Neurology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran Mansoureh Togha Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Ali Asghar Okhovat Headache Department, Iranian Center of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran Mahsa Hatami Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mohsen Sedighiyan Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Mahmoud Djalali Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Niyaz Mohammadzadeh-Honarvar Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran 2017 04 15 2017 08 01 Migraine is a common chronic inflammatory neurological disease with the progressive and episodic course. Much evidence have shown a role of inflammation in the pathogenesis of migraine. Omega-3 fatty acids are an important components of cell membranes phospholipids. The intake of these fatty acids is related to decrease concentration of C-reactive protein (CRP), proinflammatory eicosanoids, cytokines, chemokines and other inflammation biomarkers. Many of clinical trials have shown the beneficial effect of dietary supplementation with omega-3 fatty acids in inflammatory and autoimmune diseases in human, including Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Alzheimer’s disease (AD), multiple sclerosis (MS) and migraine headaches. Therefore, omega-3 fatty acids as an alternative therapy can be potentially important. This review focuses on the pathogenesis of a migraine, with an emphasis on the role of omega-3 fatty acid and its molecular mechanisms. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/1283 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/1283/357