Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 94 100 Mojtaba Mahmoodi Health Policy Research Center AND School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Anahid Safari Department of Pharmacology, School of Medicine, Islamic Azad University, Kazeroon Branch, Kazeroon, Iran. Mehrdad Vossoughi Department of Dental Public Health, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Fatemeh Golbon-Haghighi Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Maliheh Kamali-Sarvestani Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Haleh Ghaem Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Afshin Borhani-Haghighi Clinical Neurology Research Center AND Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 14 Background: The aim was to assess the reliability and the validity of the translated version of the stroke specific quality of life (SS-QOL) questionnaire in Iranian post-stroke patients. Methods: This project was performed at the Shiraz University of Medical Sciences, Shiraz, Iran, between 12  April  2010  and  24  February 2011.  The  English version of the SS-QOL was translated into Persian by “forward-backward” translation, cognitive inquiring and cultural adaptation process. The reliability and internal consistency were measured by Cronbach’s alpha coefficient. Validity was assessed using convergent and divergent validity through Spearman’s correlation coefficient. Results: Our study included 117 post-stroke patients, consisting of 57 (48.7%) men and 60 (51.3%) women. The mean age of the patients was 81.60 ± 7.52 (range 60-88) years. The Persian version of the SS-QOL proved reliable (Cronbach’s α = 0.96). Internal consistency was excellent for both demographic and patients’ clinical characteristics (Cronbach’s α ≥ 0.70). The scaling success rates were 100% for convergent validity of each scale. Divergent validity for all 12 scales was considered acceptable, whereas each scale had a 100% scaling success rate for convergent validity. Conclusion: The Persian version of SS-QOL should be mentioned as a noteworthy instrument to specify different  aspects  of  health  related  QOL  of  patients suffering stroke and hence that clinicians, researchers and epidemiologist can exploit it trustfully. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/564 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/564/238