Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 1 2015 03 15 8 11 Mohammad Abdollahi Iranian Center of Neurological Research AND Department of Neurology, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mansoureh Toghae Iranian Center of Neurological Research AND Department of Neurology, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. Firoozeh Raisi Psychiatric and Clinical Psychology Research Center, Roozbeh Psychiatric Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Elaheh Saffari Iranian Center of Neurological Research AND Department of Neurology, School of Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 14 Background: Female sexual dysfunction (FSD) defines as any disorder in the process of sexual contact including 6 main domains, desire, arousal, lubrication,  orgasm,  orgasm  satisfaction  and  pain. This study was conducted to evaluate prevalence of sexual dysfunction disorder in women with migraine headache and also find the associated factors related to migraine characteristics. Methods: A total of 69 eligible woman patients fulfilling criteria for migraine participated in this study. The Female Sexual Function Index (FSFI), a multi- dimensional self-report implement for appraisal of Female Sexual Function during the past month were utilized in this study. The information related to migraine including frequency, duration of headache attack, severity of headache according to visual analog scale (VAS) score  and  headache impact  test  (HIT)  score were obtained using a self-administrated questionnaire. Results: About 68.4% of patients had an FSFI score < 28. In  domains of  desire 73.7%, arousal 64.9%, lubr cation 21.1%, orgasm 33.3%, satisfaction 17.5%, associated with FSD. Serotonin mechanisms such as 5HT2, 5HT3 agonist have been hypothesized as  a shared etiology for migraine and sexual dysfunction. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/580 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/580/222