Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 13 3 2014 09 15 177 180 Anahid Safari Clinical Neurology Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Esmail Jafari Department of Ophthalmology, Division of Corneal Disease, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Afshin Borhani-Haghighi Department of Neurology, School of Medicine AND Clinical Neurology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 14 Morning glory syndrome (MGS) is a rare congenital optic disc anomaly characterized by a funnel-shaped, excavated optic disc surrounded by chorioretinal pigmentary disturbance. The main ophthalomoscopic feature of the MGS is enlarged optic disc with a funnel shaped scleral defect; elevated peripapillary chorioretinal pigmentation; and pale fluffy tissue of glial hyperplasia overlying the optic disc. Although most of the reported cases were isolated ocular abnormality, but it may occurs in association with other ophthalmic abnormalities such as cyst of the optic nerve atrophy, congenital cataract, microophthalmos, and aniridia. Craniofacial deformities such as cleft lip and palate, hypertelorism, dysplatic ears; renal abnormalities; and cardiac defects have also been reported with MGS. Herein, we present a case of MGS associated with multiple sclerosis - a rather unusual concurrence. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/599 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/599/203