Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 13 3 2014 09 15 160 167 Roya Abolfazli Department of Neurology, School of Medicine, Amiralam Hospital, Tehran University of Medical Sciences, Tehran, Iran. Azam Elyasi Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Javadi Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Kheirollah Gholami Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. Hassan Torkamandi Department of Pharmaceutical Care, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Amir-Shahkarami Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Masoud Etemadifar Department of Neurology, Isfahan Neurosciences Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Zahra Nasr Department of Medicine, Medical Students' Research Center, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2015 10 14 Background:  Multiple  sclerosis  (MS) patients permanently confronted  with serious challenges from treatment regimen. Developing  a new  questionnaire in MS management, through  evaluation  of patients’ perspectives   and  knowledge   regarding   treatment  will help  to  identify the  sources  of tension, and  to  build  a therapeutic   alliance.   We   purposed   to   describe    MS patients’ understanding of their treatments. Methods: About 425 completed and returned questionnaire were assessed  of a total of 500 recruited  MS patients. The knowledge   of  correct  using  interferon-beta  (IFN-β)  and attitude   toward  medical  care  were  assessed   using  self- reported questionnaires consisted of 25 items with validity of multidisciplinary panel and pre-testing on 20 patients. Results:  Knowledge  about  IFN-β  therapy  was  very low; however, attitude  was at a high level. Female patients, self- injection ability, higher educational level, normal functional status, delay from the start of diagnostic workup to definite diagnosis, and being younger were related to a higher level of  knowledge.  Attitude  was  associated   with  functional status,  family  history  of  disease   and   the   summary  of knowledge variable. Conclusion: Developing educational  interventions  are needed for MS patients  regarding  to  their  low levels of knowledge. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/602 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/602/200