Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 13 2 2014 06 15 105 107 Mojtaba Azimian Department of Clinical Sciences, School of Medicine, Tehran University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Azam Shahvarughi-Farahani Department of Clinical Sciences, School of Medicine, Tehran University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Mahdi Rahgozar Department of Clinical Sciences, School of Medicine, Tehran University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Masoud Etemadifar Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Zahra Nasr Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran ; Department of Medical Sciences, School of Medicine, Medical Students' Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. 2015 10 14 Background: Fatigue, depression, and physical impairment are common  among  multiple  sclerosis (MS) patients. The aim  of  this  study was to  determine  the   relationship between depression,  physical impairment,  and  fatigue  in an Iranian MS cohort. Methods: Fifty consecutive  relapsing-remitting MS patients and  50 age- and  sex-matched healthy  controls (HCs) were recruited  from Sina Rehabilitation Clinic,Tehran, ran. The depression  substance of Hospital Anxiety and  Depression Scale (HADS), Expended Disability Status Scale, and Fatigue Severity Scale questionnaires were used  to  assess depression, physical impairment, and fatigue, respectively. Results: This study included 38 (76%) females and 12 (24%) males  in  both  patients and  HC groups. The  depression substance of the  HADS  in MS and  HCs showed  a mean value of 1.92 ± 0.80 and 1.17 ± 0.38, respectively (P < 0.001). Pearson’s correlation analyses showed that in the MS group depression    was  associatedwith fatigue (r  =  0.54, P =  0.01),  but  not  with  physical  impairment  (r =  0.16, p =   0.01),while fatigue   was   associated with both depression  (r = 0.54, P = 0.01) and  physical impairment (r =  0.36,  P =  0.01).  Depression  in HCs group  was  also associated with fatigue (r -0.64, P = 0.01). Conclusion: Fatigue  is associated   with  both  depression and  physical  impairment, and  an  intervention  in one  of these conditions might improve others. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/613 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/613/189