Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 12 4 2013 12 15 157 165 Majid Ghaffarpour Professor, Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. Hossein Pakdaman Professor, Department of Neurology, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Hossein Harirchian Professor, Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran Hossein-Ali Ghelichnia Omrani Assistant Professor, Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran Mojdeh Ghabaee Associate Professor, Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran Babak Zamani Assistant Professor, Rasool-e Akram Hospital, Iran University of Medical Sciences, Tehran, Iran Parviz Bahrami Associate Professor, Department of Neurology, Lorestan University of Medical Sciences, Lorestan, Iran Bahaadin Siroos Resident, Department of Neurology, Imam Khomeini Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 The new-AEDs, whose developments were motivated following the discovery of the valproate and its marketing in the U.S in 1978, have presented more therapeutic options. There are approximately twenty four FDA-approved antiepileptic drugs for use in patients with epilepsy, five of which were identified and have come on to the market between 2009 and 2012. The new-AEDs are of interest, not due to their efficacy, but rather owing to better tolerance, favorable pharmacokinetic profile, fewer interactions, and in some instances, lesser protein binding. No standard AED or those in developing have all properties of an ideal antiepileptic drug, thus to achieve desirable outcome, physicians should be aware of pharmacokinetics (PKs) and pharmacodynamics (PDs) of drugs. This review describes briefly the major features of the new AEDs. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/638 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/638/164