Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 12 4 2013 12 15 144 148 Navid Mohammadi Associate Professor, Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran. Shiva Kian Community and Preventive Medicine Specialist, Iran University of Medical Sciences, Tehran, Iran Farnoush Davoudi Assistant Professor, Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran Seyed Mohammad Ali Akbarian Nia Assistant Professor, Department of Neurology, Iran University of Medical Sciences, Tehran, Iran Marzieh Nojomi Professor, Department of Community Medicine, Iran University of Medical Sciences, Tehran, Iran 2015 10 14 Background: Health assessment in patients  with epilepsy (PWE) should  include  both  clinical outcomes and  health related quality of life (HRQOL) measures. The quality of life (QoL) in epilepsy-31 inventory  (QOLIE-31) is widely used for QOL studies  in epilepsy. This study  aims to evaluate psychometrics  of the Persian version of the inventory (QOLIE-31-P). Methods:  Following a  standard  forward-backward translation  and cultural adaptation, the construct  validity of the QOLIE-31-P  was  assessed  by  explanatory factor analysis, multi-trait  scaling  analysis, and  known group comparison. The criterion validity  was   assessed   by calculating   the   Pearson   correlation   to  SF-36 (36-item short-form health  survey). The reliability was assessed  by calculating Cronbach’s alpha and test-retest study. Results: The  factor analysis  extracted   from  8  factors explaining  70.35%  of  the  variations. Item-scale correlations  revealed  that  individual items  significantly had  the strongest  association  with  the  domain   they were  loaded on. The Pearson  coefficient  of correlation between QOLIE-31-P and the overall scores of SF-36 was 0.876  (P <  0.0001).  Patient  with  medically  controlled seizures  scored  higher than  those  who  experienced seizures   during the  previous year  to  study  date (P <  0.0001).  The Cronbach’s  α  of  overall  QOLIE-31-P inventory  was 0.9. The overall test-retest coefficient  of correlation was 0.68 (P = 0.003). Conclusion: QOLIE-31-P is a valid and reliable tool to be applied in health assessment of patients with epilepsy. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/640 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/640/162