Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 12 3 2013 09 15 114 116 Masoud Mehrpour Assistant Professor, Department of Neurology AND Firoozgar Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Motamed Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mahboubeh Aghaei Health Policy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Zahra Badi Research Center for Traditional Medicine and History of Medicine AND Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran 2015 10 14 Stroke is an important cause of disability and death worldwide, with the majority of strokes occurring in older people. Thrombolysis with recombinant tissue plasminogen activator (r-TPA) is the approved treatment for acute ischemic stroke. A major concern of physicians, who treat acute ischemic stroke with recombinant tissue plasminogen activator (r-TPA,) is the risk of intracerebral hemorrhage. However, other adverse reactions, including anaphylaxis and angioedema, can also occur. Here we report an interesting soft tissue reaction to intravenous r-TPA in an 80 year-old male who was treated for acute ischemic stroke. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/647 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/647/155