Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 12 3 2013 09 15 102 105 Hosein Shamshiri Resident, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Reza Eshraghian Professor, Department of Statistics and Epidemiology, School of Health, Tehran University of Medical Sciences, Tehran, Iran Nastaran Ameli Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences, Tehran, Iran Shahriar Nafissi Associate professor, Department of Neurology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Background: As a disease of motor nervous system (motor neuron  disease), amyotrophic  lateral  sclerosis (ALS)  has  a great  impact  on  several  aspects  of  quality  of  life (QoL). Generic questionnaires of QoL do not address all the especial features  of ALS and  therefore  translation  and  validation of disease specific questionnaires such as Amyotrophic Lateral Sclerosis Assessment  Questionnaire  40-item  (ALSAQ-40)  is necessary for assessment of patients with different languages. The aim of this study was to review the validation of the Persian version of the ALSAQ-40. Methods:  Meticulously  translated ALSAQ-40   was completed by 21 ALS patients. Internal reliability was evaluated   using  Cronbach’s  alpha  coefficient  and item- total correlation  was also used  to evaluate  the correlation of each  question  with total  score.Validity was evaluated through  comparison with Amyotrophic Lateral Sclerosis Functional Rating Scale-revised (ALSFRS-r)and the 36-Itemhort Form Health Survey (SF-36). Results: Cronbach’s alpha coe<cient was 0.91-0.96 for different scales of the ALSAQ-40. All the 40 questions of the questionnaire had correlation greater  than 0.5. Correlation coefficient of all the related scales of the Persian version of ALSAQ-40, SF-36 and ALSFRS-r was greater  than  0.59 with P value < 0.001. Conclusion: Measures of the Cronbach’s alpha coefficient and item-total correlation demonstrated reliability and consistency of the questionnaire, and correlation coefficients confirmed the validity of different items in the questionnaire. This study showed that the Persian version of the ALSAQ-40 is a reliable and valid questionnaire for the evaluation of QoL in ALS patients with Persian language. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/650 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/650/152