Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 12 1 2013 03 15 32 34 Mohammad Hossein Harirchian Professor, Iranian Center of Neurological Research, Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Somayeh Nasergivechi Professor, Iranian Center of Neurological Research, Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Marzieh Maddah Immunology, Allergy and Asthma Research Institute, Tehran University of Medical Sciences, Tehran, Iran Alipasha Meysamie Associate Professor, Department of Community and Preventive Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Homayoun Amini Associate Professor, Psychiatry and Psychology Research Center, Tehran University of Medical Sciences, Tehran, Iran Ehsan Esmaelii Shandiz Iranian Center of Neurological Research, Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Abbas Tafakhori Assistant Professor, Iranian Center of Neurological Research, Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 14 Background: Fatigue, a major cause of disability in individuals with multiple sclerosis (MS), is associated with reduced quality of life. The aim of this study was to evaluate the reliability and reproducibility of the Persian version of Modified Fatigue Impact Scale (MFIS) in Iranian patients with MS. Methods: This study included 15 subjects with clinically definite MS, 15 hospitalized patients with MS, and 15 hospitalized patients with other chronic illnesses (as controls). They filled in the Persian version of the MFIS twice with a three-day interval. MFIS items were analyzed and the correlation coefficient was calculated. Results: There was a good correlation between the scores of the two measurements (correlation coe9cient: 0.984, P < 0.001) especially in physical and cognitive subgroups. The reproducibility of psychosocial subscale was lower than physical and cognitive subscales. Conclusion:According to our findings, the Persian version of the MFIS has a good reliability and reproducibility for assessment of fatigue in patients with MS. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/668 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/668/134