Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 11 1 2012 03 15 25 27 Majid Ghasemi Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Farzad Fatehi Department of Neurology, Shariati Hospital, Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran Bahador Asadi AJA University of Medical Sciences, Tehran, Iran Fariborz Khorvash Department of Neurology, Isfahan Neuroscience Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 2015 10 17 Amyotrophic lateral sclerosis (ALS), the most common form of motor neuron disease, is a progressive and devastating disease involving both lower and upper motor neurons, typically following a relentless progression towards death. Therefore, all efforts must be made by the clinician to exclude alternative and more treatable entities. ALS with laboratory abnormalities of uncertain significance is a subgroup of ALS that occurs in association with laboratory defined abnormalities that are of uncertain significance to the pathogenesis of ALS. The clinical utility of these abnormalities and what they ultimately mean in patients with ALS is discussed here, along with a review of the literature. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/836 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/836/101