Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 10 3-4 2011 12 15 46 50 Alia Saberi Poursina Hospital, Department of Neurology, Guilan University of Medical Sciences, Rasht, Iran. Hamid Reza Hatamian Poursina Hospital, Department of Neurology, Guilan University of Medical Sciences, Rasht, Iran Ehsan Kazemnejad Poursina Hospital, Department of Neurology, Guilan University of Medical Sciences, Rasht, Iran Nasim Ghorbannejad Poursina Hospital, Department of Neurology, Guilan University of Medical Sciences, Rasht, Iran 2015 10 17 Background: Some coincidental disorders with migraine have been introduced that may have role in its pathogenesis or aggravation. In this study we determined the relative frequency of hyperlipidemia as a coincidental disorder in patients affected by migraine. Methods: A total of 102 migraine-affected patients according to International Headache Society (HIS) criteria and 103 control subjects adjusted for age participated in this case-control study. Their serum level of triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured. Results: A total of 84 women and 18 men with mean age of 34.9 ± 11.8 years and 79 women and 24 men with mean age of 32.8 ± 5.7 years constituted case and control groups, respectively. The means of serum triglyceride, total cholesterol, HDL-C and LDL-C levels in case and control groups were 177.0 ± 118.2 versus 108.7 ± 37.2 mg/dl (P = 0.0001), 186.2 ± 44.1 versus 152.9 ± 3.7 mg/dl (P = 0.0001), 49.9 ± 12.5 versus 46.1 ± 10.7 mg/dl (P = 0.023) and 104.8 ± 33.7 versus 84.1 ± 34.0 mg/dl (P = 0.0001), respectively. The prevalence of hypertriglyceridemia and hypercholesterolemia in case and control groups were 41.2% versus 18.4% (P = 0.0001), and 36.3% versus 9.7% (P = 0.0001). According to multivariate analysis, odds ratios were 3.11 (95% CI: 1.4 -6.6) and 17.4 (95% CI: 2.12-138.3), respectively. Odds ratio for low HDL-C was 0.2 (95% CI: 0.08-0.49). Conclusion: Hypertriglyceridemia and hypercholesterolemia were more frequent in migraineurs. Conversely, low HDL-C was less frequent among the patients compared with non-migraineurs. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/845 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/845/247