Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 2 2016 04 08 80 84 EN Faraidoon Haghdoost Medical Student Research Center AND Physiology Research Center, Isfahan University of ‎Medical Sciences, Isfahan, Iran Mahsa Gharzi Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Farough Faez Pharmacy Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Elinaz Hosseinzadeh Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Mohamadhasan Tajaddini Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Laleh Rafiei Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Fatemeh Asgari Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Mahboobeh Banihashemi Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Samaneh Sadat Masjedi Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Alireza Zandifar Medical Student Research Center, Isfahan University of Medical Sciences, Isfahan, Iran‎ Shaghayegh Haghjooy-Javanmard Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran 2015 11 06 2016 04 08 Background: Migraine is a common neurovascular disorder with multifactorial and polygenic inheritance. The aim of this study was to investigate the association of a migraine without aura and Ala379Val polymorphism of lipoprotein-associated phospholipase A2 (Lp-PLA2) gene in the Iranian population. Methods: In this study, 103 migraine patients and 100 healthy controls were enrolled. DNA samples were extracted and the Ala379Val polymorphism of Lp-PLA2 gene was investigated. To assess severity of a headache, patients filled out the headache impact test (HIT-6) and migraine severity (MIGSEV) questionnaires. Results: Allele V had significantly lower frequency in the case group than control subjects [P = 0.001, odds ratio (OR) = 0.25, confidence interval (CI): 0.15-0.40]. The frequency of migraine patients that were a carrier of V allele (V/V and A/V) was statistically significant lower than the control group (P = 0.003, OR = 2.39, CI: 1.35-4.23). There was no significant difference of alleles frequency between three grades of MIGSEV (P = 0.316). Furthermore, total HIT-6 score was not significantly different between different genotypes (P = 0.466). Conclusion: Our results showed that Ala379Val gene polymorphism of LP-PLA2 is associated with lower risk of migraine but not with severity of headaches in an Iranian population. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/883 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/883/280