Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2016 02 20 1 1 EN Iranian Journal of Neurology Iranian Journal of Neurology Official journal of Iranian Neurologyical Association 2016 02 20  No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/996 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/996/264

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 59 66 Reza Karami Student Research Committee, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mahmoud Hosseini Neurocognitive Research Center AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Toktam Mohammadpour Neurogenic Inflammation Research Center AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Ahmad Ghorbani Pharmacological Research Center of Medicinal Plants AND Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hamid Reza Sadeghnia Pharmacological Research Center of Medicinal Plants AND Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Hassan Rakhshandeh Pharmacological Research Center of Medicinal Plants AND Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Farzaneh Vafaee Neurogenic Inflammation Research Center AND Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Mahdi Esmaeilizadeh Esfarayen Faculty of Medical Sciences, Esfarayen, Iran. 2015 10 14 Background: An important role for oxidative stress, as a consequence of epileptic seizures, has been suggested. Coriandrum sativum has been shown that have antioxidant effects. Central nervous system depressant effects of C. sativum have also been reported. In this study, the effects of hydroalcoholic extract of aerial parts of the plants on brain tissues oxidative damages following seizures induced by pentylenetetrazole (PTZ) was investigated in rats. Methods: The rats were divided into five groups and treated: (1) Control (saline), (2) PTZ (90 mg/kg, i.p.), (3-5) three doses (100, 500 and 1000 mg/kg of C. sativum extract (CSE) before PTZ. Latencies to the first minimal clonic seizures (MCS) and the first generalized tonic-clonic seizures (GTCS) were recorded. The  cortical and hippocampal tissues were then removed for biochemical measurements. Results: The extract significantly increased the MCS and GTCS latencies (P < 0.01, P < 0.001) following PTZ-induced seizures. The malondialdehyde (MDA) levels in both cortical and hippocampal tissues of PTZ group were significantly higher than those of the control animals (P < 0.001). Pretreatment with the extract prevented elevation of the MDA levels (P < 0.010–P < 0.001). Following PTZ administration, a significant reduction in total thiol groups was observed in both cortical and hippocampal tissues (P < 0.050). Pretreatment with the 500 mg/kg of the extract caused a significant prevention of decreased in total thiol concentration in the cortical tissues (P < 0.010). Conclusion: The present study showed that the hydroalcoholic extract of the aerial parts of C. sativum possess significant antioxidant and anticonvulsant activities. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/569 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/569/233

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 67 73 Masoud Etemadifar Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Mohsen Janghorbani Department of Epidemiology and Biostatistics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. 2015 10 14 Background: The aim of this preliminary study was to assess the safety and efficacy of high-dose oral vitamin D3 supplementation during pregnancy in women with multiple sclerosis (MS) in Isfahan, Iran. Methods:In a single center open-label randomized, controlled clinical Phase I/II pilot study, 15 pregnant women with confirmed MS with low serum 25-hydroxyvitamin D (25(OH)D) levels were randomly allocated to receive either 50,000 IU/week vitamin D3 or routine care from 12 to 16 weeks of gestation till delivery. The main outcome measures were mean change in serum 25(OH)D levels, expanded disability status scale (EDSS) score, and number of relapse events during pregnancy and within 6 months after delivery. Results: Average serum 25(OH)D level at the end of trial in vitamin D3 supplemented group was higher than routine care group (33.7 ng/mL vs. 14.6 ng/ml, P < 0.050). In vitamin D3 group, the mean EDSS did not changed 6 months after delivery (P > 0.050), whereas in routine care group, the mean EDSS increased from 1.3 (0.4) to 1.7 (0.6) (P < 0.070). Women in vitamin D3 group appeared to have fewer relapse events during pregnancy and within 6 months after delivery. No significant adverse events occurred. Conclusion:Adding high dose vitamin D3 supplementation during pregnancy to routine care of women with MS had significant effect on the serum 25(OH)D levels, EDSS and number of relapse events during pregnancy and within 6 months after delivery. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/568 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/568/234

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 74 80 Omid Sadeghi Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Morteza Nasiri Department of Research Committee, School of Nursing and Midwifery, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Zahra Maghsoudi Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Naseh Pahlavani Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. Masoud Rezaie Department of Research Committee, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. Gholamreza Askari Food Security Research Center AND Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. 2015 10 14 Background:Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine  supplementation on severity, frequency and duration of migraine attacks as well as headache diary results (HDR). Methods:This double-blind randomized clinical trial study was conducted on 66 patients with migraine with aura (MA) in Khorshid and Emam Mosa Sadr clinics of Isfahan University of Medical Sciences, Iran, in 2013. Patients were randomly allocated to receive either pyridoxine supplements (80 mg pyridoxine per day) or placebo. Severity, frequency and duration of migraine attacks and HDR were measured at baseline and at the end of the study. Results:Mean age of patients was 34.24 ± 9.44 years old. Pyridoxine supplementation led to a significant decrease in headache severity (-2.20 ± 1.70 compared with -1 ± 1.50; P = 0.007), attacks duration (-8.30 ± 12.60 compared with -1.70 ± 9.60; P = 0.030) and HDR (-89.70 ± 134.60 compared with -6.10 ± 155.50; P = 0.040) compared with placebo, but was not effective on the frequency of migraine attacks (-2.30 ± 4 compared with -1.20 ± 7.80; P = 0.510). Conclusion:Pyridoxine supplementation in patients with MA was effective on headache severity, attacks duration and HDR, but did not affect the frequency of migraine attacks. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/567 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/567/235

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 81 85 Ghazaleh Eskandari Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Mahsa Ghajarzadeh Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Mir Saeed Yekaninejad Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Ali Sahraian MS Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Razieh Gorji Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. Faezeh Rajaei Iranian Center of Neurological Research, Tehran University of Medical Sciences, Tehran, Iran. Abbas Norouzi-Javidan Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Alireza Faridar Department of Neurology, Houston Methodist Hospital, Weill Cornell Medical College, Houston, TX. Amirreza Azimi Brain and Spinal Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 14 Background: Multiple sclerosis (MS) is an autoimmune,  neuro- inflammatory disease  of  central nervous system affecting physical, emotional, and cognitive aspects of patients. Association of vitamin D deficiency and MS has been shown in previous studies. The aim of this study was to evaluate serum vitamin D level in MS cases and their sex-matched healthy siblings (who are genetically near similar) and non-relative sex-matched healthy controls. Methods: A total of 135 subjects enrolled in this case- control study. Group one (n = 45) consisted of patients with established MS. Group two (n = 45) included sex- matched healthy siblings of the group one and group three participants (n = 45) were non-relative sex- matched  healthy  controls.  Demographic  data  (age, sex), level of education, daily sun exposure duration, and month of birth gathered for all. Serum sample of all participants was collected for 25-hydroxy vitamin D measurement. Results: There was no significant difference between vitamin D level, sun exposure duration, education level, and season of birth in three evaluated groups. Mean vitamin D level was 8.2 ± 10.1 (nmol/l) in women and 13.3 ± 7 (nmol/l) in men (P = 0.001). There was a significant positive correlation between daily sun exposure duration and vitamin D level in whole participants (r = 0.28, P < 0.001) as well as in MS patients (r = 0.32, P = 0.030). Mean vitamin D level was significantly lower  in  participants  who  have  born  in spring and summer. Conclusion:  Vitamin  D  deficiency  is  high  among Iranian population as well as MS patients. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/566 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/566/236

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 86 93 Kandadai Rukmini Mridula Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Rupam Borgohain Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Shaik Afshan Jabeen Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Gaddamanugu Padmaja Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Vcs Srinivasarao Bandaru Department of Research, Yashoda Hospital Somajiguda Hyderabad, India. Praveen Ankathi Department of Neurosurgery, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Meena A Kanikannan Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. Mohammed Shujath Ali Khan Department of Neurology, Nizam's Institute of Medical Sciences, Autonomous University, Hyderabad, India. 2015 10 14 Background: Non motor symptoms (NMS) of idiopathic Parkinson’s disease (PD) are a major cause of disability and recognition of these symptoms and treatment is important for comprehensive health care. Deep   brain   stimulation   of   bilateral   subthalamic nucleus deep brain stimulation (STN DBS) has been shown to improve motor symptoms in PD and effects on NMS are unknown. To investigate the NMS among PD patients who underwent STN DBS. Methods: We recruited prospectively 56 patients with PD, who had undergone bilateral STN DBS and 53 age and duration of illness  matched PD patients on dopaminergic therapy (controls). NMS were assessed using 30 item questionnaire NMS Quest. These questions  evaluated  9 domains, gastrointestinal, urinary,  cardiovascular, sexual, cognition (apathy/attention/memory), anxiety/depression, hallucinations/delusions, sleep an dmiscellaneous. Comparison was done on individual symptoms as well as  in  various  domains.  This  study  was  carried  at Nizam’s  Institution  of  Medical  Sciences  and  study period was from January 2011 to December 2012. Results:  Patients  who underwent STN  DBS  had  a significantly lower  mean  total  score  on  NMS  quest (6.7   ±   3.8)   compared   to   controls   (8.4   ±   3.7) (P   <   0.00100).  Symptoms   in   the   domains   of cardiovascular, gastrointestinal, sleep were significantly less    frequent  while  sexual  disturbances  were significantly more frequent among patients compared to controls.  On  individual  symptom  analysis,  nocturia (P  <  0.00010),  unexplained  pains  (P  <  0.00010), nausea  and  vomiting,  constipation,  lightheadedness, depression, and insomnia were less prevalent, while sexual disturbances were significantly more common in STN DBS group compared to controls. Conclusion: Bilateral STN DBS not only improves the motor symptoms but also improves many NMS in PD patients. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/565 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/565/237

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 94 100 Mojtaba Mahmoodi Health Policy Research Center AND School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. Anahid Safari Department of Pharmacology, School of Medicine, Islamic Azad University, Kazeroon Branch, Kazeroon, Iran. Mehrdad Vossoughi Department of Dental Public Health, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. Fatemeh Golbon-Haghighi Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Maliheh Kamali-Sarvestani Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. Haleh Ghaem Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. Afshin Borhani-Haghighi Clinical Neurology Research Center AND Department of Neurology, Shiraz University of Medical Sciences, Shiraz, Iran. 2015 10 14 Background: The aim was to assess the reliability and the validity of the translated version of the stroke specific quality of life (SS-QOL) questionnaire in Iranian post-stroke patients. Methods: This project was performed at the Shiraz University of Medical Sciences, Shiraz, Iran, between 12  April  2010  and  24  February 2011.  The  English version of the SS-QOL was translated into Persian by “forward-backward” translation, cognitive inquiring and cultural adaptation process. The reliability and internal consistency were measured by Cronbach’s alpha coefficient. Validity was assessed using convergent and divergent validity through Spearman’s correlation coefficient. Results: Our study included 117 post-stroke patients, consisting of 57 (48.7%) men and 60 (51.3%) women. The mean age of the patients was 81.60 ± 7.52 (range 60-88) years. The Persian version of the SS-QOL proved reliable (Cronbach’s α = 0.96). Internal consistency was excellent for both demographic and patients’ clinical characteristics (Cronbach’s α ≥ 0.70). The scaling success rates were 100% for convergent validity of each scale. Divergent validity for all 12 scales was considered acceptable, whereas each scale had a 100% scaling success rate for convergent validity. Conclusion: The Persian version of SS-QOL should be mentioned as a noteworthy instrument to specify different  aspects  of  health  related  QOL  of  patients suffering stroke and hence that clinicians, researchers and epidemiologist can exploit it trustfully. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/564 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/564/238

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 101 107 Ahmad Reza Khatoonabadi Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Noureddin Nakhostin-Ansari Department of Physiotherapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Amin Piran Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. Hamid Tahmasian Department of Speech Therapy, School of Rehabilitation, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 14 Background:  The  Mississippi  Aphasia  Screening Test (MAST) is a brief screening test for assessing the expressive and receptive language abilities in patients with  aphasia.  The  objective  of  the  study  was  to develop and validate the Persian version of the MAST (MASTp) as a screening test for language disorders in patients with post-stroke aphasia. Methods: This study used a cross-sectional design to cross- culturally   adapt   the   MASTp   following   the guidelines for the process of cross-cultural adaptation of measures. A total of 40 subjects (20 patients with post-stroke aphasia  and  20  healthy subjects)  were included. The MASTp was tested for floor or ceiling effects,   internal   consistency   reliability,   intra-rater reliability, discriminative validity, and factor structure. Results:  There  were  no  floor  or  ceiling  effects  for MASTp  total  score.  The  MASTp  yielded  values  for internal consistency reliability that were not adequate (Cronbach’s alpha 0.64 and 0.66 for test and retest, respectively. The  intra-rater reliability of  the  MASTp within a 7 day-interval was excellent for total score (ICC agreement =  0.96) and  both  expressive  index (ICC = 0.95) and receptive index (ICC agreement = 0.98). here were statistically  ignificant differences in MASTp total scores and both indexes between patients and healthy subjects suggesting the discriminative validity of the MASTp (P < 0.001). Factor analysis revealed a 3- factor solution, which jointly accounted for 72.06% of the total variance. Additional factor analysis suggested 6-item MASTp as a unidimensional measure. Conclusion:  The  MASTp  is  useful  as  a  valid  and reliable screening tool for evaluation of language abilities in Persian speaking patients with aphasia after stroke. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/563 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/563/239

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 108 109 Nasim Tabrizi Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. Mahmoud Abedini Department of Neurology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. 2015 10 14 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/562 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/562/240

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 110 112 Süha Akpınar Deparment of Radiology, Near East University Faculty of Medicine, Nicosia, North Cyprus, Turkey. Güliz Yılmaz Deparment of Radiology, Near East University Faculty of Medicine, Nicosia, North Cyprus, Turkey. Emre Çelebioğlu Deparment of Radiology, Burhan Nalbantoğlu State Hospital, Nicosia, North Cyprus, Turkey. 2015 10 14 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/561 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/561/241

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 113 115 Farhad Assarzadegan Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Atoosa Gharib Department of Pathology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Shirin Behbahani Department of Neurology, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Meysam Ebrahimi-Abyaneh Department of Neurosurgery, Imam Hossein Hospital, Shahid Beheshti University of Medical Science, Tehran, Iran. 2015 10 14 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/560 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/560/242

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 2 2015 06 15 116 117 Hatice Kose Ozlece Department of Neurology, School of Medicine, Kafkas University, Kars, Turkey. Faik Ilik Department of Neurology, School of Medicine, Mevlana University, Konya, Turkey. Nergiz Huseyinoglu Department of Neurology, School of Medicine, Kafkas University, Kars, Turkey. 2015 10 14 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/559 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/559/243