Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 02 17 994 994 EN Iranian joiurnal of neurology Iranian joiurnal of neurology Official journal of Iranian Neurological Association 2016 02 17 Click to download the index of this issue. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/994 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/994/267

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 1 8 EN Mansoureh Togha ‎Headache Research Center, Iranian Center of Neurological Research, Neuroscience ‎Institute AND Department of Neurology, Sina Hospital, Tehran University of Medical ‎Sciences, Tehran, Iran Nahid Abbasi Khoshsirat Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, ‎Iran Abdorreza Naser Moghadasi ‎Headache Research Center, Iranian Center of Neurological Research, Neuroscience ‎Institute AND Department of Neurology, Sina Hospital, Tehran University of Medical ‎Sciences, Tehran, Iran Faezeh Mousavinia ‎Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, ‎Iran Mohammad Mozafari ‎Headache Research Center, Iranian Center of Neurological Research, Neuroscience ‎Institute, Tehran University of Medical Sciences, Tehran, Iran Mohamadreza Neishaboury ‎Headache Research Center, Iranian Center of Neurological Research, Neuroscience ‎Institute, Tehran University of Medical Sciences, Tehran, Iran Seyed Mahmood Mousavi ‎Headache Research Center, Iranian Center of Neurological Research, Neuroscience ‎Institute, Tehran University of Medical Sciences, Tehran, Iran 2015 11 10 2015 11 17 Background: Headaches are one of the most frequent reasons for pain in multiple sclerosis (MS) individuals. Characterization of headaches and delineating possible relationships with MS-related determinants can ultimately circumvent headaches. Methods: In a prospective case-control study, 65 Iranian relapsing- remitting MS (RRMS) patients and 65 healthy controls were recruited during patients’ admission for attack-period treatment and asked about characteristics and co-symptoms of headaches they experienced in the preceding week and usage of disease modifying drugs (DMDs) and types of MS attacks were also inquired. The same questions were asked from the same patients 3 months later in a follow-up visit. Results: A total of 57 patients and 57 controls were included in the final analyses. In total, 26 (45.6%) patients in relapse, 18 (27.7%) controls, and 22 (38.6%) patients in remission reported headaches and only significant difference existed between relapse patients and controls (P = 0.036). In headache prevalence was higher in patients in relapse phase having MS < 3 years compared to relapse patients with more than 3 years of MS (68 vs. 28.1%; P = 0.004). Other variables of interest did not differ among the three groups. Conclusion: The RRMS patients in relapse phase suffer from headaches more than healthy people do. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/889 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/889/256

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 9 15 EN Shahram Oveisgharan Rush Alzheimer’s Disease Center; Rush University Medical Center, Chicago, Illinois, USA AND ‎‎Iranian Center of Neurological Research, Shariati ‎Hospital, Tehran University of Medical ‎Sciences, Tehran, Iran Amir Babak Ghaemmaghami Iranian Center of Neurological Research, Shariati Hospital, Tehran University of Medical ‎Sciences, Tehran, Iran Ahmad Bahonar ‎Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, ‎Iran Nizal Sarrafzadegan Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Iran 2015 12 25 2015 12 25 Background: Few investigators have reported case fatality and disability of Iranian patients with stroke. This study was designed to collect morbidity and case fatality data of hospitalized patients with stroke, and stroke care quality in Isfahan, Iran. Methods: From 2006 to 2011, from overlapping sources (discharge diagnoses, attending physicians, and hospitalization wards), all hospitalized patients with possible strokes were enrolled in the study, their hospital records were summarized by experienced personnel and reviewed by a neurologist with stroke experience. Patients were followed by phone calls or visited to their addresses and their 28th day functional status was checked by translated modified Rankin Scale (mRS). Forms and methods were derived from the World Health Organization (WHO) Monitoring Trends and Determinants in Cardiovascular Disease and STEPS projects. Results: A total of 9487 patients were identified to suffer from stroke. Their ages’ mean was 68.98 ± 13.63 years, and 50.0% were females. In hospital, case fatality was 16.5% and the 28th day case fatality was 25.6%. The greatest case fatality was among intracerebral hemorrhage (ICH) patients and the least among ischemic stroke (IS) ones. Case fatality was greater among female and older patients and those with the previous history of stroke. Among survivors, only 26.9% were functionally independent (mRS < 3) which was the greatest among subarachnoid hemorrhage (SAH) patients and least among ICH patients. None of the patients were admitted to specific stroke units or received thrombolytic therapy. Conclusion: The hospitalized patients with stroke in Isfahan have unfavorable outcome compared with their mates in developed countries. A low quality of stroke care may be responsible, and urgent attention is needed. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/937 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/937/255

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 16 22 EN Sina Asaadi ‎Functional Neurosurgery Research Center, Shahid Beheshti University of Medical ‎Sciences, Tehran, Iran Farzad Ashrafi ‎Functional Neurosurgery Research Center, Shahid Beheshti University of Medical ‎Sciences, Tehran, Iran Mahmoud Omidbeigi ‎School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran , Iran‎ Zahra Nasiri ‎Functional Neurosurgery Research Center, Shahid Beheshti University of ‎Medical Sciences, Tehran, Iran Hossein Pakdaman ‎Department of Neurology, School of Medicine AND Loghman Hospital, Tehran University ‎of Medical Sciences, Tehran, Iran‎ Ali Amini-Harandi ‎Functional Neurosurgery Research Center, Shahid Beheshti University of Medical ‎Sciences, Tehran, Iran 2015 11 27 2015 12 05 Background: Cognitive impairment in patients with Parkinson’s disease (PD) mainly involves executive function (EF). The frontal assessment battery (FAB) is an efficient tool for the assessment of EFs. The aims of this study were to determine the validity and reliability of the psychometric properties of the Persian version of FAB and assess its correlation with formal measures of EFs to provide normative data for the Persian version of FAB in patients with PD. Methods: The study recruited 149 healthy participants and 49 patients with idiopathic PD. In PD patients, FAB results were compared to their performance on EF tests. Reliability analysis involved test-retest reliability and internal consistency, whereas validity analysis involved convergent validity approach. FAB scores compared in normal controls and in PD patients matched for age, education, and Mini-Mental State Examination (MMSE) score. Results: In PD patients, FAB scores were significantly decreased compared to normal controls, and correlated with Stroop test and Wisconsin Card Sorting Test (WCST). In healthy subjects, FAB scores varied according to the age, education, and MMSE. In the FAB subtest analysis, the performances of PD patients were worse than the healthy participants on similarities, fluency tasks, and Luria’s motor series. Conclusions: Persian version of FAB could be used as a reliable scale for the assessment of frontal lobe functions in Iranian patients with PD. Furthermore, normative data provided for the Persian version of this test improve the accuracy and confidence in the clinical application of the FAB. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/907 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/907/262

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 23 27 EN Masoud Mehrpour Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran‎ Fahimeh Akhoundi Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran‎ Zahra Rezaei Firoozgar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran 2015 12 13 2015 12 13 Background: To determine whether Islamic fasting would change cerebral blood flow during Ramadan. Methods: The study group comprised 20 subjects (16 males and 4 females) on a regimen of 1 month food and water intake restriction, according to Islamic fasting ritual. Subjects were evaluated for cerebral bolo flow through a middle cerebral artery (MCA) by means of transcranial Doppler (TCD), the day before starting Ramadan fasting and the day after the month of Ramadan. Results: Our results showed no statistically significant changes after Ramadan in cerebrovascular hemodynamic, in comparison before Ramadan. Conclusion: Although some studies showed metabolic changes during Ramadan fasting (increasing hematocrite, decreasing amount of hemoglobin, dehydration, platelet aggregation, and lipid profile alternations) the findings suggest that Islamic fasting has no significant effects on cerebral blood flow. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/925 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/925/254

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 28 33 EN Azar Mehri ‎Department of Speech Therapy, School of Rehabilitation, Tehran University of ‎Medical Sciences, Tehran, Iran Askar Ghorbani Department of Neurology, School of Medicine, Tehran University of Medical ‎Sciences, Tehran, Iran Ali Darzi ‎Department of Linguistics, School of Letters and Humanities, ‎University of Tehran, Tehran, Iran Shohreh Jalaie ‎Department of Physiotherapy, School of Rehabilitation, Tehran University of ‎Medical Sciences, Tehran, Iran Hassan Ashayeri ‎Department of Rehabilitation, School of Rehabilitation, Iran University of Medical ‎Sciences, Tehran, Iran 2015 11 16 2015 12 27 Background: Cerebrovascular disease leading to stroke is the most common cause of aphasia. Speakers with agrammatic non-fluent aphasia have difficulties in production of movement-derived sentences such as passive sentences, topicalized constituents, and Wh-questions. To assess the production of complex sentences, some passive, topicalized and focused sentences were designed for patients with non-fluent Persian aphasic. Afterwards, patients’ performance in sentence production was tested and compared with healthy non-damaged subjects. Methods: In this cross sectional study, a task was designed to assess the different types of sentences (active, passive, topicalized and focused) adapted to Persian structures. Seven Persian patients with post-stroke non-fluent agrammatic aphasia (5 men and 2 women) and seven healthy non-damaged subjects participated in this study. The computed tomography (CT) scan or magnetic resonance imaging (MRI) showed that all the patients had a single left hemisphere lesion involved middle cerebral artery (MCA), Broca`s area and in its white matter. In addition, based on Bedside version of Persian Western Aphasia Battery (P-WAB-1), all of them were diagnosed with moderate Broca aphasia. Then, the production task of Persian complex sentences was administered. Results: There was a significant difference between four types of sentences in patients with aphasia [Degree of freedom (df) = 3, P < 0.001]. All the patients showed worse performance than the healthy participants in all the four types of sentence production (P < 0.050). Conclusion: In general, it is concluded that topicalized and focused sentences as non-canonical complex sentences in Persian are very difficult to produce for patients with agrammatic non-fluent aphasia. It seems that sentences with A-movement are simpler for the patients than sentences involving A`-movement; since they include shorter movements in compare to topicalized and focused sentences. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/897 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/897/258

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 34 45 EN Mansour Parvaresh-Rizi ‎Department of Neurosurgery, School of Medicine AND Rasoul-E-Akram ‎Hospital, Iran University of Medical Sciences, Tehran, Iran Alireza Tabibkhoei ‎Department of Neurosurgery, School of Medicine AND Rasoul-E-Akram ‎Hospital, Iran University of Medical Sciences, Tehran, Iran Gholamali Shahidi ‎Department of Neurosurgery, School of Medicine AND Rasoul-E-Akram ‎Hospital, Iran University of Medical Sciences, Tehran, Iran Janardan Vaidyanathan ‎Medtronic, Mumbai, India Amirreza Tabibkhoei ‎Department of Neurosurgery, School of Medicine AND Rasoul-E-Akram ‎Hospital, Iran University of Medical Sciences, Tehran, Iran Mohammad Rohani ‎Department of Neurosurgery, School of Medicine AND Rasoul-E-Akram ‎Hospital, Iran University of Medical Sciences, Tehran, Iran 2016 01 01 2016 01 01 Background: Subthalamic nucleus (STN) stimulation is the  reatment of choice for carefully chosen patients with idiopathic Parkinson's disease (PD) and refractory motor fluctuations. We evaluated the value of intraoperative electrophysiology during STN deep brain stimulation (DBS) procedures in refining the anatomically-defined target. Methods: We determined the spatial distance between the anatomical and physiological targets along x, y and z axes in 50 patients with PD who underwent bilateral subthalamic nucleus DBS surgery. Results: The mean spatial distance between anatomical and functional targets was 1.84 ± 0.88 mm and the least distances in different methods were 0.66 mm [standard error (SE): 0.07], 1.07 mm (SE: 0.08) and 1.01 mm (SE: 0.08) on x, y and z axes, respectively, for the combined method. Conclusion: The most physiologically-accurate anatomical targeting was achieved via a combination of multiple independent methods. There was a statistically significant difference between the anatomical and functional targets in all methods (even the combined) on the y coordinate, emphasizing the need for intra- operative electrophysiological monitoring to refine the anatomico-radiologically-defined target. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/949 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/949/261

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 46 53 EN Chris Hahn Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, ‎Boston, USA Mohammad Kian Salajegheh Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, ‎Boston, USA 2015 11 16 2015 11 16 The myotonic disorders are a heterogeneous group of genetically determined diseases that are unified by the presence of myotonia, which is defined as failure of muscle relaxation after activation. The presentation of these disorders can range from asymptomatic electrical myotonia, as seen in some forms of myotonia congenita (MC), to severe disability with muscle weakness, cardiac conduction defects, and other systemic features as in myotonic dystrophy type I (DM1). In this review, we describe the clinical features and pathophysiology of the different myotonic disorders, their laboratory and electrophysiologic findings and briefly review the currently available treatments. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/898 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/898/260

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 54 56 EN Somayyeh Baghizadeh Iranian Center of Neurological Research, Iranian Headache Association, Sina Hospital, Tehran ‎University of Medical Sciences ,Tehran, Iran Mohammad Ali Sahraian Department of Neurology, School of Medicine AND Sina Hospital, Tehran University of Medical ‎Sciences ,Tehran, Iran Mojgan Ghahari Iran Multiple Sclerosis Society, Tehran, Iran‎ 2015 11 04 2016 01 01 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/879 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/879/257

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 57 59 EN Alireza Vakilian Geriatric Care Research Center, Rafsanjan University of Medical Sciences, Rafsanjan, Iran‎ Amir Moghadam-Ahmadi Clinical Research Development Center, Rafsanjan University of Medical Sciences, Rafsanjan, ‎Iran‎ Habib Farahmand Department of Radiology, Ali-Ebn Abitaleb Hospital, Rafsanjan University of Medical Sciences, ‎Rafsanjan, Iran 2015 12 13 2015 12 13 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/924 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/924/253

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 15 1 2016 01 06 60 61 EN Mansoureh Togha Professor, Iranian Center of Neurological Research, Sina Hospital, Tehran University of Medical ‎Sciences, Tehran, Iran‎ 2016 01 06 2016 01 06 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/953 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/953/259