Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 1 1 EN Iranian Journal of Neurology Iranian Journal of Neurology Official Journal of Iranian Neurological Association 2016 02 20 Click to download the index of this issue.   https://ijnl.tums.ac.ir/index.php/ijnl/article/view/998 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/998/268

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 185 189 EN Kazem Anvari Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mahmoud Reza Kalantari Department of Pathology, School of Medicine, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Fariborz Samini Department of Neurosurgery, School of Medicine, Shahid Kamiab Hospital, Mashhad University of Medical Sciences, Mashhad, Iran Soodabeh Shahidsales Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mehdi Seilanian-Toussi Cancer Research Center AND Department of Radiation Oncology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Zakiyeh Ghorbanpour Department of Radiation Oncology, School of Medicine, Omid Hospital, Mashhad University of Medical Sciences, Mashhad, Iran 2015 10 11 Background: Intracranial lesions of the pituitary gland are common pituitary adenomas, accounting for 6-10% of all symptomatic intracranial tumors. In this retrospective study, the clinicopathologic features and survival rate of pituitary adenomas were evaluated. Methods: The present retrospective study was conducted on 83 patients with pituitary adenomas, referring to radiation oncology departments of Ghaem and Omid Hospitals, Mashhad, Iran, over a period of 13 years (1999-2012). Data obtained from clinical records including clinical features, type of surgery (if performed), treatment modality, overall survival rate, and progression-free survival rate were analyzed. Results: Eighty-three patients including 44 males (53%) and 39 females (47%) participated in this study. The median age was 40 years (age range: 10-69 years). Chiasm compression was reported in 62 patients (74.4%), and 45.78% of the subjects suffered from headaches. Functional and non-functional adenomas were reported in 44 (53.01%) and 39 (46.99%) patients, respectively. In cases with functional and non-functional adenomas, the disease was controlled in 95 and 84.5% of the subjects for 3 years, respectively. Furthermore, 1- and 3-year survival rates for functional adenoma were 84.6 and 23%, respectively; the corresponding values were 90.9 and 22.7% in non-functional adenomas, respectively. Conclusion: In this study, a significant correlation between headache severity and type of adenoma was observed. So, application of surgery and radiotherapy together could be a highly effective approach for treating functional adenomas, although it is less efficient for the non-functional type. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/273 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/273/251

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 190 194 EN Mohammad Mehdi Heidari Department of Biology, School of Science, Yazd University, Yazd, Iran Mehri Khatami Department of Biology, School of Science, Yazd University, Yazd, Iran Shahriar Nafissi Department of Neurology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Faezeh Hesami-Zokai Department of Biology, School of Science, Yazd University, Yazd, Iran Afshin Khorrami Department of Biology, School of Science, Yazd University, Yazd, Iran 2015 10 11 Background: Non-dystrophic myotonias are a heterogeneous set of skeletal, muscular channelopathies, which have been associated with point mutations within sodium channel α-subunit (SCN4A) gene. Because exons 22 and 24 of SCN4A gene are recognized as hot spots for this disease, the purpose of the study is to identify mutation in exons 22 and 24 of SCN4A gene in Iranian non-dystrophic myotonias patients. Methods: In this study, 28 Iranian patients with non-dystrophic myotonia analyzed for the mutation scanning in exons 22 and 24 of SCN4A gene by polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) and sequencing. Results: We found 29073G>C substitution in SCN4A gene in one case and 31506A>G substitution in seven cases. The 29073G>C substitution causes a missense mutation G1306A, located in the conserved cytoplasmic loop connecting repeat III and IV of the SCN4A channel but, 31506A>G substitution do not alter amino acid in SCN4A protein. Conclusion: G1306A residue is located in functionally important protein region. In “hinged-lid model” for Na+ channel inactivation in which glycines1306 act as the hinge of the lid occluding the channel pore. Mutation in this region slowed fast inactivation. Therefore, it might be a pathogenic mutation. The causal relationship of this mutation with the disease is an object for further discussion. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/280 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/280/17

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 195 203 EN Javad Hami Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Mehran Hosseini Research Centre of Experimental Medicine AND Department of Public Health, Deputy of Research and Technology, Birjand University of Medical Sciences, Birjand, Iran Sekineh Shahi Department of Biology, School of Sciences, Payame Noor University, Tehran, Iran Nassim Lotfi Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand AND Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Abolfazl Talebi School of Medicine, Birjand University of Medical Sciences, Birjand, Iran Mohammad Afshar Department of Anatomy, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran 2015 10 11 Background: Parkinson’s disease (PD) is a common neurodegenerative disease resulting from the degeneration of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc). Increasing evidence demonstrated that mice treated intranasally with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) suffered impairments in motor functions associated with disruption of DA neurons in SNc conceivably analogous to those observed in PD. L-arginine has been proposed as a novel neuroprotective agent that plays protective roles in several models of neuronal cellular damage. This study aimed to evaluate the effects of L-arginine on the numerical density of dark neurons (DNs) in the SNc of Balb/c mice subjected to MPTP administration. Methods: In the present study, we demonstrated that repeated treatment with L-arginine (300 mg/kg, i.p.) during 7 consecutive days attenuated the production of DNs in SNc of adult male Balb/c mice infused with a single intranasal administration of MPTP (1 mg/nostril). Results: Pre-treatment with L-arginine significantly decreased the numerical density of DNs in SNc of mice 21 days after intranasal MPTP administration. Conclusion: This investigation provides new insights in experimental models of PD, indicating that L-arginine represents a potential neuroprotective agent for the prevention of DA neuron degeneration in SNc observed in PD patients. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/291 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/291/18

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 204 210 EN Davood Kashipazha Department of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Seyed Ehsan Mohammadianinejad Department of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Nastaran Majdinasab Department of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Mostafa Azizi Department of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran Majid Jafari Department of Neurology, Golestan Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 2015 10 11 Background: Neuromyelitis optica (NMO) is an uncommon neuro- inflammatory syndrome that has shown to be distinct from multiple sclerosis (MS) and associated with the autoantibody marker NMO-immunoglobulin G (IgG). There are still only a few studies regarding the epidemiology of NMO in Iran. In the present study, we tried to describe the epidemiology of NMO in Khuzestan as one of the densely populated regions in Iran. Methods: A cross-sectional study was performed during the period 2013-2014. Multiple regional sources of data were used including hospital records, details from neurologists and MS society database. The diagnosis of NMO was based on clinical presentation, abnormal findings on neuroimaging and serological tests. Results: A 51 Caucasian patients (36 patients with NMO and 15 with NMO-spectrum disorder) were identified with a female/male ratio of 7.5:1.0. The crude prevalence of NMO was 1.1/100,000 population. The mean age at onset was 29.2 ± 6.1 years and the mean duration of symptoms was 5.0 ± 0.4 years. The majority of patients (60.8%) were classified as having mild disability (Expanded Disability Status Scale = 0-3.5). Among of 35 patients whose titer of NMO-IgG was measured, 19 (54.2%) were seropositive. Conclusion: Our study suggests that NMO prevalence rate in South West Iran (Khuzestan Province) is much lower than that reported for MS prevalence rate (16.2/100,000) and our patients had a lower age at onset presentation and milder course of the disease than western countries. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/301 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/301/252

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 211 218 EN Sima Rafiei Department of Health Management, School of Health, Qazvin University of Medical Sciences, Qazvin, Iran Mohammad Arab Department of Management and Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Arash Rashidian Department of Management and Health Economics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Mahmood Mahmoudi Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran Vafa Rahimi-Movaghar Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran 2015 10 12 Background: Health workforce shortages in rural and remote areas are a global challenge that almost every health system has to deal with. This study aimed to discover neurosurgeons’ job preferences and propose policy interventions that could possibly increase their retention in rural, remote, or underserved areas. Methods: A discrete choice experiment (DCE) was conducted in November 2014 with a sample of Iranian neurosurgeons selected from five contrary’s provinces representing the geographical diversity. Job attributes included income, dual practice opportunities, workload, proximity to family, clinical infrastructure, housing, educational facilities, and work location. Probit regression model was used to estimate the importance of different job attributes and examine the extent to which neurosurgeons were willing to tradeoff between monetary and nonmonetary attributes. Results: Findings indicated that increased salary, permission to undertake dual practice and access to adequate clinical infrastructure were the most important retention policies. Provision of subsidized housing and educational facilities also increased neurosurgeons’ attraction and retention in rural areas. Conclusion: A range of policy interventions focusing on both monetary and nonmonetary incentives are required to increase neurosurgeons’ retention in rural, remote, or underserved areas. https://ijnl.tums.ac.ir/index.php/ijnl/article/view/544 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/544/21

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 219 221 EN Mi Song Choi Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea Bom Choi Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea Soo Jin Cho Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea Joo Yong Kim Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea Ki Han Kwon Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea Suk Yun Kang Department of Neurology, School of Medicine, Dongtan Sacred Heart Hospital, Hallym University, Hwaseong Si, Republic of Korea 2015 10 11 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/310 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/310/19

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 222 224 EN Payam Sasannejad Department of Neurology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Ali Ghabeli-Juibary Department of Neurology, School of Medicine, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Samira Aminzadeh Department of Neurology, School of Medicine, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Nahid Olfati Department of Neurology, School of Medicine, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran 2015 10 11 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/178 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/178/15

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 225 227 EN Mohammad Reza Motamed Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Fereshteh Nasiri Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Seyed Mohammad Fereshtehnejad Care Sciences, and Society (NVS), Karolinska Institute AND Department of Neurobiology, Stockholm, Sweden AND Firoozgar Clinical Research Development Center, Firoozgar Hospital, Iran University of Medical Sciences; Tehran, Iran Masoud Mehrpour Firoozgar Clinical Research Development Center AND Department of Neurology, School of Medicine, Firoozgar Hospital, Iran University of Medical Sciences; Tehran, Iran Babak Zamani Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Bahram Haghi-Ashtiani Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Farzaneh Rohani Department of Neurology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2015 10 11 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/179 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/179/16

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 228 230 EN Shivani Patel Department of Internal Medicine, Civil Hospital, College of B.J. Medical, Gujarat University, Gujarat, India Apurva Patel Gujarat Cancer and Research Institute AND Department of Medical and Pediatric Oncology, College of B.J. Medical, Gujarat University, Gujarat, India Monil Majmundar Department of Internal Medicine, Civil Hospital, College of B.J. Medical, Gujarat University, Gujarat, India Irappa Madabhavi Gujarat Cancer and Research Institute AND Department of Medical and Pediatric Oncology, College of B.J. Medical, Gujarat University, Gujarat, India Ravi Shah Department of Internal Medicine, Civil Hospital, College of B.J. Medical, Gujarat University, Gujarat, India Jay Soni Department of Internal Medicine, Civil Hospital, College of B.J. Medical, Gujarat University, Gujarat, India 2015 10 11 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/319 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/319/20

Tehran University of Medical Sciences Current Journal of Neurology 2717-011X 14 4 2016 03 03 231 232 EN Saeed Khosrawi Department of Physical Medicine and Rehabilitation, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Lida Kianimehr Department of Physical Medicine and Rehabilitation, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Somayeh Andalib Department of Physical Medicine and Rehabilitation, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2015 10 12 No Abstract https://ijnl.tums.ac.ir/index.php/ijnl/article/view/545 https://ijnl.tums.ac.ir/index.php/ijnl/article/download/545/116