Prevalence of familial multiple sclerosis in Iran: A systematic review and meta-analysis

  • Mahmood Moosazadeh Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran
  • Ravanbakhsh Esmaeili Department of Medical-Surgical Nursing, Nasibeh School of Nursing and Midwifery, Mazandaran University of Medical Sciences, Sari, Iran
  • Mohammad Mehdi Nasehi Department of Pediatric Neurology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Ghasem Abedi Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran
  • Mahdi Afshari Department of Community Medicine, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran
  • Fereshteh Farshidi Health Sciences Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Motahareh Kheradmand Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran
Keywords:
Familial, Multiple Sclerosis, Meta-Analysis, Prevalence, Iran

Abstract

Background: Familial history of multiple sclerosis (MS) has been considered as one of the etiologic factors of MS by several studies. It is valuable to combine the results of these studies. The aim of this study is to estimate the pooled prevalence of familial MS in Iran using meta-analysis.

Methods: Using relevant keywords, national and international databanks were searched. Considering the significant heterogeneity between the results, random effect model was utilized to estimate the pooled prevalence of familial MS using Stata software.

Results: After screening the selected articles,
15 studies with total sample size of 6248 (from 60 to 1718) were identified eligible for final
meta-analysis. Overall prevalence of familial MS in Iran was estimated as of 11.4% [95% confidence interval (CI): 8.7-14.1]. Point prevalence varied between 3.3% and 26.7%.

Conclusion: Our study showed that the familial prevalence of MS among Iranian people is relatively high. More studies are warranted to investigate the effect of familial history as a risk factor for MS.

References

1. Files DK, Jausurawong T, Katrajian R,Danoff R. Multiple sclerosis. Prim Care 2015; 42(2): 159-75.
2. Esposito F, Guaschino C, Sorosina M,Clarelli F, Ferre L, Mascia E, et al.Impact of MS genetic loci on familial aggregation, clinical phenotype, and disease prediction. Neurol Neuroimmunol Neuroinflamm 2015; 2(4): e129.
3. Mansouri B, Asadollahi S, Heidari K,Fakhri M, Assarzadegan F, Nazari M, et al. Risk factors for increased multiple
sclerosis susceptibility in the Iranian population. J Clin Neurosci 2014; 21(12):2207-11.
4. Hollenbach JA, Oksenberg JR. The immunogenetics of multiple sclerosis: A comprehensive review. J Autoimmun
2015; 64: 13-25.
5. Nielsen NM, Westergaard T, Rostgaard K, Frisch M, Hjalgrim H, Wohlfahrt J, et al. Familial risk of multiple sclerosis: a
nationwide cohort study. Am J Epidemiol 2005; 162(8): 774-8.
6. Marrosu MG, Lai M, Cocco E, Loi V,Spinicci G, Pischedda MP, et al. Genetic factors and the founder effect explain
familial MS in Sardinia. Neurology 2002;58(2): 283-8.
7. Kahana E. Epidemiologic studies of multiple sclerosis: a review. Biomed Pharmacother 2000; 54(2): 100-2.
8. Carton H, Vlietinck R, Debruyne J, De KJ, D'Hooghe MB, Loos R, et al. Risks of multiple sclerosis in relatives of patients
in Flanders, Belgium. J Neurol Neurosurg Psychiatry 1997; 62(4): 329-33.
9. Ebers GC, Koopman WJ, Hader W,Sadovnick AD, Kremenchutzky M,Mandalfino P, et al. The natural history of
multiple sclerosis: a geographically based study: 8: familial multiple sclerosis. Brain 2000; 123(Pt 3): 641-9.
10. Hader WJ, Yee IM. The prevalence of familial multiple sclerosis in saskatoon, Saskatchewan. Mult Scler Int 2014; 2014:
545080.
11. Hashemilar M, Savadi Ouskui D,Farhoudi M, Ayromlou H, Asadollahi A. Multiple sclerosis in East Azerbaijan,
North West Iran. Neurology Asia 2011;16(2): 127-31.
12. Etemadifar M, Abtahi SH. Multiple sclerosis in Isfahan, Iran: Past, present and future. Int J Prev Med 2012; 3(5):
301-2.
13. Moosazadeh M, Nekoei-Moghadam M, Emrani Z, Amiresmaili M. Prevalence of unwanted pregnancy in Iran: a systematic review and meta-analysis. Int J HealthPlann Manage 2014; 29(3): e277-e290.
14. von Elm E, Altman DG, Egger M, Pocock SJ, Gotzsche PC, Vandenbroucke JP. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Prev Med
2007; 45(4): 247-51.
15. Ashtari F, Shaygannejad V, Heidari F,Akbari M. Prevalence of familial multiple sclerosis in Isfahan, Iran. J Isfahan Med
Sch 2011; 29(138): 555-61. [In Persian].
16. Baghizadeh S, Sahraian MA,Beladimoghadam N. Clinical and demographic factors affecting disease severity in patients with multiple sclerosis. Iran J Neurol 2013; 12(1): 1-8.
17. Danesh-Sani SA, Rahimdoost A, Soltani M, Ghiyasi M, Haghdoost N, Sabzali- Zanjankhah S. Clinical assessment of
orofacial manifestations in 500 patients with multiple sclerosis. J Oral Maxillofac Surg 2013; 71(2): 290-4.
18. Ghabaae M, Qelichnia Omrani H,Roostaeizadeh M. Epidemiology of multiple sclerosis in Tehran: A three year
study. Tehran Univ Med J 2007; 65(5):74-7. [In Persian].
19. Mazaheri S, Fazlian MM, Hossein Zadeh A. Clinical and epidemiological features of early and adult onset multiple sclerosis in Hamedan, Iran, 2004–2005. Yafteh2008; 9(4): 39-44. [In Persian].
20. Payamani F, Miri M. Survey of symptoms and side effects in patients with multiple sclerosis. Nursing Development in Health 2012; 2(2-3):45-50. [In Persian].
21. Pourmemari M, Rabie S, Bagheri H, Taghiloo G, Eskandari F. Epidemiologic variables in Multiple sclerosis patients in
Zanjan. Holist Nurs Midwifery 2011; 21(1): 1-6. [In Persian].
22. Rezaali S, Khalilnezhad A, Naser Moghadasi A, Chaibakhsh S, Sahraian MA. Epidemiology of multiple sclerosis
in Qom: Demographic study in Iran. IranJ Neurol 2013; 12(4): 136-43.
23. Rezaie AA, Panahi MS. Descriptive cross sectional study of clinical manifestation and MRI finding in 60 multiple sclerosis patients. Sci J Hamadan Univ Med Sci 2005; 12(3): 53-6. [In Persian].
24. Saadatnia M, Etemadifar M, Maghzi AH. Multiple sclerosis in Isfahan, Iran. Int Rev Neurobiol 2007; 79: 357-75.
25. Taraghi Z, Ilali E, Abedini M, Zarvani A, Khoshnama I, Mohammadpour RA, et al. Quality of life among multiple sclerosis patients. Iran J Nurs 2007; 20(50): 51-9. [In Persian].
26. Kalanie H, Gharagozli K, Kalanie AR. Multiple sclerosis: report on 200 cases from Iran. Mult Scler 2003; 9(1): 36-8.
27. Nasehi MM, Sahraian MA, Naser Moghaddasi A, Ghofrani M, Ashtari F, Taghdiri MM, et al. Clinical and Epidemiological Aspects of Multiple Sclerosis in Children. Iran J Child Neurol 2017; 11(2): 37-43.
28. Saman-Nezhad B, Rezaee T, Bostani A,Najafi F, Aghaei A. Epidemiological characteristics of patients with multiple
sclerosis in Kermanshah, Iran in 2012. J Mazandaran Univ Med Sci 2013; 23(104): 97-101. [In Persian].
29. El-Salem K, Al-Shimmery E, Horany K, Al-Refai A, Al-Hayk K, Khader Y. Multiple sclerosis in Jordan: A clinical
and epidemiological study. J Neurol 2006; 253(9): 1210-6.
30. Fricska-Nagy Z, Bencsik K, Rajda C, Fuvesi J, Honti V, Csepany T, et al. Epidemiology of familial multiple sclerosis in Hungary.Mult Scler 2007; 13(2): 260-1.
31. Willer CJ, Dyment DA, Cherny S, Ramagopalan SV, Herrera BM, Morrison KM, et al. A genome-wide scan in forty
large pedigrees with multiple sclerosis. J Hum Genet 2007; 52(12): 955-62.
Published
2017-04-19
How to Cite
1.
Moosazadeh M, Esmaeili R, Nasehi MM, Abedi G, Afshari M, Farshidi F, Kheradmand M. Prevalence of familial multiple sclerosis in Iran: A systematic review and meta-analysis. Curr J Neurol. 16(2):90-95.
Section
Review Article(s)