Iranian Journal of Neurology 2017. 16(2):78-82.

Atherogenic indices in stroke patients: A retrospective study
Rajaragupathy Sujatha, Subramanian Kavitha


Background: Stroke makes a significant cause of morbidity and mortality worldwide. Although derangements in the lipid profile have been suggested as a risk factor for the development of stroke, various studies show inconsistent results on the association between lipid profile and stroke. A very few studies have commented on the status of lipid indices in stroke patients.

Methods: After obtaining ethical medical records of the study populations were analyzed, and data collected from patients admitted to the hospital with clinically diagnosed stroke and control group consisted of apparently healthy volunteers selected from the master health checkup department. Baseline characteristics and lipid profile parameters and the number of days of hospital stay for stroke patients were collected. Lipid indices were calculated using following formulae. Atherogenic index of plasma (AIP) = log triglyceride/high-density lipoprotein cholesterol (HDLc), Castelli’s Risk Index (CRI-I) = Total cholesterol/HDLc, CRI-II = Low density lipoprotein cholesterol/HDLc, atherogenic coefficient
(AC) = (Total cholesterol−HDLc)/HDLc, and
non-HDLc (NHC) = Total cholesterol–HDL.

Results: The study included 620 participants of which 290 were stroke patients and 330 healthy volunteers. 61% of stroke patients were hypertensives and 38% were diabetics 28% were both diabetic and hypertensives. In this study, the lipid parameters and the indices were significantly higher in stroke patients than the control group. Three indices, namely, CRI-I, AC, and NHC were found to be contributing to the risk of stroke significantly. There was no statistically significant correlation between the duration of hospital stay and lipid indices or individual parameters of
lipid profile.

Conclusion: In this study, the atherogenic lipid indices were significantly higher in stroke patients compared to controls.


Stroke; Lipid Profile; Atherogenic Indices

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Stroke WH. Recommendations on stroke prevention, diagnosis, and therapy. Report of the WHO Task Force on Stroke and other Cerebrovascular Disorders. Stroke. 1989 Oct;20(10):1407-31.

Choudhury MJ, Chowdhury MT, Nayeem A, Jahan WA. Modifiable and Non-Modifiable Risk Factors of Stroke: A Review Update. Journal of National Institute of Neurosciences Bangladesh. 2015 Apr 28;1(1):22-6.

Pandian JD, Sudhan P. Stroke epidemiology and stroke care services in India. J Stroke. 2013 Sep 1;15(3):128-34..

Dobiášová M. Atherogenic index of plasma logtriglycerides/HDL-cholesterol)]: theoretical and practical implications. Clinical Chemistry. 2004 Jul 1;50(7):1113-5

Stampfer MJ, Sacks FM, Salvini S, Willett WC, Hennekens CH. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. New England Journal of Medicine. 1991 Aug 8;325(6):373-81.

Wu J, Chen S, Liu L, Gao X, Zhou Y, Wang C, Zhang Q, Wang A, Hussain M, Sun B, Wu S. Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke: a result from the Kailuan study. Neurological research. 2013 Jun 1;35(5):505-11.

Kinosian B, Glick H, Garland G. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 1994;121:641–647

Togha, Mansoureh, et al. "Lipid profile in cerebrovascular accidents." Iranian journal of neurology 10.1-2 (2011): 1.

Sacco, Ralph L. "Newer risk factors for stroke." Neurology 57.suppl 2 (2001): S31-S34.

Shahar E, Chambless LE, Rosamond WD, et al. Plasma lipid profile and incident ischemic stroke. The atherosclerosis risk in communities (ARIC) study. Stroke. 2003;33:623–631.

Bowman TS, Sesso HD, Ma J, et al. Cholesterol and the risk of ischemic stroke. Stroke. 2003;34:2930–2934.

Park JH, Lee J, Ovbiagele B. Nontraditional serum lipid variables and recurrent stroke risk. Stroke. 2014 Nov 1;45(11):3269-74.

Guo X, Li Z, Sun G, Guo L, Zheng L, Yu S, Yang H, Pan G, Zhang Y, Sun Y. Comparison of four nontraditional lipid profiles in relation to ischemic stroke among hypertensive Chinese population. International journal of cardiology. 2015 Aug 4;201:123.


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