Association of Helicobacter pylori antibodies and severity of migraine attack

  • Behnaz Ansari Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Keivan Basiri Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Rokhsareh Meamar Mail Isfahan Neurosciences Research Center, Al-zahra Hospital, Isfahan University of Medical Sciences AND Department of Medical Sciences, School of Medicine, Islamic Azad University, Najafabad Branch, Isfahan, Iran
  • Ahmad Chitsaz Department of Neurology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
  • Shahrzad Nematollahi Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
Helicobacter Pylori, Migraine, Head Pain


Background: Recent studies have shown a positive correlation between Helicobacter pylori infection and migraine headache. The aim of this study was to evaluate the role of H. pylori infection in migraine headache with (MA) and without aura (MO).
Methods: This is a case-control study containing information on 84 patients (including MA, MO) and 49 healthy individuals. The enzyme-linked immunosorbent assay (ELISA) test was used to measure immunoglobulin G (IgG,) immunoglobulin M (IgM) titer in two groups. Headache severity was evaluated according to Headache Impact Test (HIT6) questionnaire.
Results: Mean ± SD of IgM antibody in Migrainous patients 26.3 (23.1) showed significantly difference with control group 17.5 (11.2) (P = 0.004). In addition, the mean ± SD HIT6 in Migrainous patients differed significantly between MA and MO groups 65.5 (4.7), 54.9 (5.3) respectively, P < 0.001). The only significant correlation was found for IgG antibody and HIT6 in MA patients (r = 0.407, P = 0.011) and MO group (r = 0.499, P = 0.002). The risk of migraine occurrence in patients did not significantly associate with the level of IgG and IgM antibodies.
Conclusion: The results give a hope that definite treatment and eradication of this bacterium could be a cure or to reduce the severity and course of migraine headaches.


1. Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine headache in the United States. Relation to age, income, race, and other sociodemographic factors. JAMA 1992; 267(1): 64-9.
2. Diener HC, Kaube H, Limmroth V. A practical guide to the management and prevention of migraine. Drugs 1998; 56(5):811-24.
3. de Vries B, Frants RR, Ferrari MD, van den Maagdenberg AM. Molecular genetics of migraine. Hum Genet 2009; 126(1): 115-32.
4. Deleu D, Hanssens Y, Worthing EA. Symptomatic and prophylactic treatment of migraine: a critical reappraisal. Clin Neuropharmacol 1998; 21(5): 267-79.
5. Jahromi SR, Abolhasani M, Meysamie A, Togha M. The effect of body fat mass and fat free mass on migraine headache. Iran J Neurol 2013; 12(1): 23-7.
6. Jones R, Lydeard S. Irritable bowel syndrome in the general population. BMJ 1992; 304(6819): 87-90.
7. Holtmann G, Goebell H, Holtmann M, Talley NJ. Dyspepsia in healthy blood donors. Pattern of symptoms and association with Helicobacter pylori. Dig Dis Sci 1994; 39(5): 1090-8.
8. Imanieh MH, Dehghani SM, Haghighat M, Irani M, Yousefi M. Migraine headache and acid peptic diseases in children. Iran Red Crescent Med J 2009; 11(2): 181-3.
9. Gasbarrini A, De LA, Fiore G, Franceschi F, Ojetti V, V, Torre ES, et al. Primary Headache and Helicobacter Pylori. Int J Angiol 1998; 7(4): 310-2.
10. Gasbarrini A, Gabrielli M, Fiore G, Candelli M, Bartolozzi F, De LA, et al. Association between Helicobacter pylori cytotoxic type I CagA-positive strains and migraine with aura. Cephalalgia 2000; 20(6): 561-5.
11. Yiannopoulou KG, Efthymiou A, Karydakis K, Arhimandritis A, Bovaretos N, Tzivras M. Helicobacter pylori infection as an environmental risk factor for migraine without aura. J Headache Pain 2007; 8(6): 329-33.
12. Hosseinzadeh M, Khosravi A, Saki K, Ranjbar R. Evaluation of Helicobacter pylori infection in patients with common migraine headache. Arch Med Sci 2011; 7(5): 844-9.
13. Pacifico L, Anania C, Osborn JF, Ferraro F, Chiesa C. Consequences of Helicobacter pylori infection in children. World J Gastroenterol 2010; 16(41): 5181-94.
14. Tunca A, Turkay C, Tekin O, Kargili A, Erbayrak M. Is Helicobacter pylori infection a risk factor for migraine? A case-control study. Acta Neurol Belg 2004; 104(4): 161-4.
15. Bradbeer L, Thakkar S, Liu A, Nanan R. Childhood headache and H. pylori--a possible association. Aust Fam Physician 2013; 42(3): 134-6.
16. Asghari N, Nassaji M, Shojaei H, Mosavi Sh, Ghorbani R. The effect of helicobacter pylori eradication on migraine without aura. Ir J Neurol 2013; 12(Suppl 1): 65.
17. Faraji F, Zarinfar N, Zanjani AT, Morteza A. The effect of Helicobacter pylori eradication on migraine: a randomized, double blind, controlled trial. Pain Physician 2012; 15(6): 495-8.
18. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Headache Classification Committee of the International Headache Society. Cephalalgia 1988; 8(Suppl 7): 1-96.
19. Bagley CL, Rendas-Baum R, Maglinte GA, Yang M, Varon SF, Lee J, et al. Validating Migraine-Specific Quality of Life Questionnaire v2.1 in episodic and chronic migraine. Headache 2012; 52(3): 409-21.
20. Pinessi L, Savi L, Pellicano R, Rainero I, Valfre W, Gentile S, et al. Chronic Helicobacter pylori infection and migraine: a case-control study. Headache 2000; 40(10): 836-9.
21. Caselli M, Chiamenti CM, Soriani S, Fanaro S. Migraine in children and Helicobacter pylori. Am J Gastroenterol 1999; 94(4): 1116-8.
22. Malaty HM, Graham DY. Importance of childhood socioeconomic status on the current prevalence of Helicobacter pylori infection. Gut 1994; 35(6): 742-5.
23. Bakhshipour A, Momeni M, Ramroodi N. Effect of Helicobacter Pylori Treatment on the Number and Severity of Migraine Attacks. Zahedan J Res Med Sci 2012; 14(6): 6-8.
24. Gasbarrini A, De LA, Fiore G, Gambrielli M, Franceschi F, Ojetti V, et al. Beneficial effects of Helicobacter pylori eradication on migraine. Hepatogastroenterology 1998; 45(21): 765-70.
25. Gervil M, Ulrich V, Kaprio J, Olesen J,Russell MB. The relative role of genetic and environmental factors in migraine without aura. Neurology 1999; 53(5): 995-9.
26. Mavromichalis I, Zaramboukas T, Giala MM. Migraine of gastrointestinal origin. Eur J Pediatr 1995; 154(5): 406-10.
27. Pradalier A, Devars du Mayne JF. Migraines and digestive disorders. Gastroenterol Clin Biol 2005; 29(2): 156-61.
28. Ware JE, Bjorner JB, Kosinski M. Practical implications of item response theory and computerized adaptive testing: a brief summary of ongoing studies of widely used headache impact scales. Med Care 2000; 38(9 Suppl): II73-II82.
29. Kosinski M, Bayliss MS, Bjorner JB, Ware JE, Garber WH, Batenhorst A, et al. A six- item short-form survey for measuring headache impact: the HIT-6. Qual Life Res 2003; 12(8): 963-74.
30. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative Helicobacter pylori infection. Gut 1997; 40(3): 297-301.
31. Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI. Mucosal tumour necrosis factor alpha and interleukin-6 in patients with Helicobacter pylori associated gastritis. Gut 1991; 32(12): 1473-7.
32. Crabtree JE. Role of cytokines in pathogenesis of Helicobacter pylori-induced mucosal damage. Dig Dis Sci 1998; 43(9 Suppl): 46S-55S.
33. HirscHl AM. Helicobacter pylori pathogens, pathomecanism and epidemiology. Wien Klin Wochenschr 1994; 106(17): 535-42.
34. Nagata K, Yu H, Nishikawa M, Kashiba M, Nakamura A, Sato EF, et al. Helicobacter pylori generates superoxide radicals and modulates nitric oxide metabolism. J Biol Chem 1998; 273(23): 14071-3.
35. Ciancarelli I, Di MC, Tozzi-Ciancarelli MG, De MG, Marini C, Carolei A. Helicobacter pylori infection and migraine. Cephalalgia 2002; 22(3): 222-5.
36. Tunca A, Ardicoglu Y, Kargili A, Adam B. Migraine, Helicobacter pylori, and oxidative stress. Helicobacter 2007; 12(1): 59-62.
37. Budzynski J. The favourable effect of Helicobacter pylori eradication therapy in patients with recurrent angina-like chest pain and non-responsive to proton pump inhibitors - a preliminary study. Arch Med Sci 2011; 7(1): 73-80.
How to Cite
Ansari B, Basiri K, Meamar R, Chitsaz A, Nematollahi S. Association of Helicobacter pylori antibodies and severity of migraine attack. Curr J Neurol. 14(3):125-129.
Special Articles